Replacing yet another NBC show, the Helen Hunt and Paul Reiser starrer Mad About You, Caroline... is based on life of Caroline Duffy (Lea Thompson, Back to the Future), an accomplished cartoonist searching for love and happiness or, at least, some good material for her weekly comic strip. The strip tittled 'Caroline in the City' gets transformed into a merchandising goldmine, with an array of greeting cards, books and calendars.

Created by Barron/Pennette Productions and Three Sisters Entertainment in association with CBS Entertainment Productions, the show is produced by Fred Barron (Dave's World, The Larry Sanders Show), Marco Pennette (Dave's World) and David Nichols (Grace Under Fire ).

Other characters in the sitcom include Eric Lutes(Frasier ), as Del Cassidy, Caroline's sometime boyfriend and fiancé, who owns the greeting card company that produces "Caroline in the City" cards, Andy Lauer (21 Jump Street ) as Charlie, Del's bizarre messenger/delivery person, Amy Pietz (Muscle ) as Annie Spadaro, Caroline's best friend and next door neighbour, a Broadway actress with an offbeat dating life that is chronicled in the strip, Malcolm Gets (Mrs. Parker ,Vicious Circle ) as Richard Karinsky, the struggling, brooding artist who pays his rent by working as her cartoon colorist and Tom LaGrua as Remo, proprietor of the neighborhood restaurant.

The show when premiered on NBC in the 1995-1996 was the number one primetime series. With its second season, it established itself as a bona fide hit, giving NBC its best Tuesday rating at 9-9:30 pm in seven years. Caroline in... was a consistently top-rated, primetime comedy, and an integral part of NBC's popular 'Must-She TV' Monday night line-up. In addition, Caroline... has become one of the top-selling US comedies worldwide, airing on leading foreign broadcast and cable networks.

Following its popularity in US, the Indian premier on Star World enjoyed a successful but brief stint. Inspired by the show, Star Plus had also launched a show Krishna Sharma CA starring Shraddha Nigam, which unfortunately did not enjoy a good run and had to be revamped.

The distinctive illustrations of cartoonist Bonnie Timmons, which accent each episode of the series, won an Emmy Award in 1996 for "Outstanding Individual Achievement in Graphic Design and Title Sequences."